Reacción #3926

Ecuación de reacción

1-(4-fluorobenzyl)piperazine

potassium hydroxide

1-bromo-3-chloropropane

→

1-(4-fluorobenzyl)-4-(3-chloropropyl) piperazine dihydrochloride

Rendimiento 179.2%

Disolventes

dimethyl sulfoxide

Condiciones de reacción

Procedimiento

The procedure described in Example 1(a) was followed, using 32.8 g of 1-(4-fluorobenzyl)piperazine, 30.0 g of potassium hydroxide, 100 ml of dimethyl sulfoxide and 27.0 g of 1-bromo-3-chloropropane. Work-up, as described above, gave 35.2 g (61% of theory) of 1-(4-fluorobenzyl)-4-(3-chloropropyl) piperazine dihydrochloride as a white crystalline solid.

Fuente