Reacción #3887

Ecuación de reacción

phenyl isocyanate

3-(4-benzylpiperazin-1-yl)propanethiol dihydrochloride

triethylamine

→

N-phenyl-S-[3-(4-benzylpiperazin-1-yl)propyl]thiocarbamate dihydrochloride monohydrate

Rendimiento 41.9%

Disolventes

methylene chloride

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe mixture was refluxed for four hours
2. 2
   Lavadowashed with water
3. 3
   Secadodried (sodium sulfate)
4. 4
   OtroPrecipitation of the salt with ethereal hydrochloric acid

Procedimiento

1.6 g of phenyl isocyanate were added to a solution of 4.0 g of 3-(4-benzylpiperazin-1-yl)propanethiol dihydrochloride and 2.6 g of triethylamine in 50 ml of methylene chloride. The mixture was refluxed for four hours, washed with water and dried (sodium sulfate). Precipitation of the salt with ethereal hydrochloric acid gave 1.2 g (20% of theory) of N-phenyl-S-[3-(4-benzylpiperazin-1-yl)propyl]thiocarbamate dihydrochloride monohydrate as a white crystalline solid, M.p. 216°-219° C.

Fuente