Reacción #3881

ord-df3ebfe50c8c461e85592be41123da00

Ecuación de reacción

COC(=O)CN.Cl
glycine methyl ester hydrochloride
CSCC[C@@H](NC(=O)OC(C)(C)C)C(=O)O
t-butoxycarbonyl-D-methionine
→
COC(=O)CNC(=O)[C@@H](CCSC)NC(=O)OC(C)(C)C
title compound
COC(=O)CNC(=O)[C@@H](CCSC)NC(=O)OC(C)(C)C
t-butoxycarbonyl-D-methionylglycine methyl ester

Reactantes

COC(=O)CN.Cl
glycine methyl ester hydrochloride
CSCC[C@@H](NC(=O)OC(C)(C)C)C(=O)O
t-butoxycarbonyl-D-methionine

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    OtroThe crude product was recrystallized from ethyl acetate/Skellysolve B

Procedimiento

The title compound was prepared by the general method of Example 1 using 24.9 g (0.1 mole) of t-butoxycarbonyl-D-methionine (BOC-D-Met) and 13.8 g (0.11 mole) of glycine methyl ester hydrochloride. The crude product was recrystallized from ethyl acetate/Skellysolve B to give the title compound, which was used in subsequent reactions without further purification.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US04722922uspto-grants-1988_02