Reacción #3880

Ecuación de reacción

title compound

t-butoxycarbonyl-N-(6-methoxy-6-oxohexyl)-L-phenylalaninamide

hydrogen chloride dioxane

→

title compound

N-(6-methoxy-6-oxohexyl)-L-phenylalaninamide monohydrochloride

Disolventes

dioxane

Condiciones de reacción

Tratamiento posterior

1. 1
   ConcentraciónAfter about 30 min. the solution was concentrated in vacuo to dryness
2. 2
   Otrothe residue triturated thoroughly with diethyl ether
3. 3
   OtroThe solid was collected
4. 4
   Lavadowashed well with diethyl ether

Procedimiento

To a solution of the title compound of Example 2 (43.1 g, 0.11 mole) in 100 ml of dioxane was added 100 ml of 6M hydrogen chloride/dioxane. After about 30 min. the solution was concentrated in vacuo to dryness and the residue triturated thoroughly with diethyl ether. The solid was collected and washed well with diethyl ether, giving 34.7 g of the title compound, which was used in subsequent reactions without further purification.

Fuente