Reacción #3806

Ecuación de reacción

2,2'-dithiobisbenzoyl chloride

4-tert-butylaniline

→

title compound

Rendimiento 12.1%

2,2'-Dithiobis[N-[4-(1,1-dimethylethyl)phenyl]benzamide]

Rendimiento 12.1%

Disolventes

dichloromethane

pyridine

Condiciones de reacción

Tratamiento posterior

1. 1
   ConcentraciónThe mixture was concentrated
2. 2
   Otrothe residue triturated with 5% aqueous HCl
3. 3
   Filtraciónthe resulting solid was collected by filtration
4. 4
   Lavadowashed with water
5. 5
   Otroto yield the crude product
6. 6
   OtroThe crude material was recrystallized from ethyl ether-ethanol

Procedimiento

A solution of 2,2'-dithiobisbenzoyl chloride (1.20 g, 3.50 mmol) in 25 mL of dichloromethane was added to a solution of 4-tert-butylaniline (1.04 g, 6.99 mmol) in 8 mL of pyridine at 23° C. The reaction mixture was stirred for 18 hours at 23° C. under nitrogen atmosphere. The mixture was concentrated, the residue triturated with 5% aqueous HCl, and the resulting solid was collected by filtration and washed with water to yield the crude product. The crude material was recrystallized from ethyl ether-ethanol to yield 0.24 g of the title compound, mp 135°-138° C.

Fuente