Reacción #379

Ecuación de reacción

COC(=O)c1ccc(I)cc1O

CC(C)(C)OC(=O)N1CCNC

→

COC(=O)c1ccc(N2CCN(C

Disolventes

COCCOC

Condiciones de reacción

Procedimiento

tert-butyl piperazine-1-carboxylate (0.670 g, 3.60 mmol) and methyl 2-hydroxy-4-iodobenzoate (1 g, 3.60 mmol), BINAP (0.224 g, 0.36 mmol), cesium carbonate (2.461 g, 7.55 mmol) were put inDME (18 mL), tris(dibenzylideneacetone)dipalladium(0) (0.165 g, 0.18 mmol) was added last. Reaction wsa purged by nitrogen, and heated at90 °C overnight. No desired product was found.

Fuente