Reacción #3754

Ecuación de reacción

ethanol

1,2,3,4-tetrahydronaphthalene-2-carboxylic acid (2-amino-4,6-dioxo-3,5-dipropylcyclohex-1-enyl)amide

potassium hydroxide

hydrochloric acid

→

1,3-Dipropyl-8-(1,2,3,4-tetrahydronaphthalen-2-yl)-3,9-dihydropurine-2,6-dione

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaAfter cooling to 0° C.
2. 2
   OtroAdd water (100 ml) and collect the resulting precipitate
3. 3
   Filtraciónby suction filtration
4. 4
   OtroPurify the white solid by flash chromatography (50% ethyl acetate/hexane)
5. 5
   Otrotriturate with 5% diethyl ether/hexane
6. 6
   Otroto provide
7. 7
   Secadoafter drying under vacuum at 120° C. for 30 minutes the title compound (1.04 g), m.p. 202°-204° C.

Procedimiento

Dissolve 1,2,3,4-tetrahydronaphthalene-2-carboxylic acid (2-amino-4,6-dioxo-3,5-dipropylcyclohex-1-enyl)amide (2.0 g, 5.2 mmol) in ethanol (50 ml), add 15% potassium hydroxide (50 ml) and heat to 70° C. for 4 hours. After cooling to 0° C., acidify the reaction with concentrated hydrochloric acid (13 ml). Add water (100 ml) and collect the resulting precipitate by suction filtration. Purify the white solid by flash chromatography (50% ethyl acetate/hexane) and triturate with 5% diethyl ether/hexane to provide, after drying under vacuum at 120° C. for 30 minutes the title compound (1.04 g), m.p. 202°-204° C.

Fuente