Reacción #3752

Ecuación de reacción

1,3-di-n-propyl-5,6-diaminouracil

N-methylmorpholine

3-phenylbutyric acid

tetrahydrofuran

isobutyl chloroformate

→

N-(2-amino-4,6-dioxo-3,5-dipropylcyclohex-1-enyl)-3-phenylbutyramide

Disolventes

diethyl ether

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrothe reaction at -20° C. for 3 hours
2. 2
   workup.ADDITIONThen dilute
3. 3
   Otroseparate the layers
4. 4
   LavadoRinse the organic layer with saturated sodium bicarbonate (200 ml), 50% aqueous sodium chloride (2×200 ml)
5. 5
   Secadodry over anhydrous magnesium sulfate
6. 6
   Filtraciónfilter
7. 7
   Concentraciónconcentrate under vacuum

Procedimiento

Dissolve 3-phenylbutyric acid (1.0 g, 6.1 mmol) in tetrahydrofuran (20 ml), treat with N-methylmorpholine (0.67 ml, 6.1 mmol) and cool to -20° C. Add isobutyl chloroformate (0.79 ml, 6.1 mmol) and stir for 20 minutes. Then add 1,3-di-n-propyl-5,6-diaminouracil (1.4 g, 6.1 mmol, in 5 ml dimethylformamide) and stir the reaction at -20° C. for 3 hours. Then dilute the reaction with diethyl ether (400 ml) and separate the layers. Rinse the organic layer with saturated sodium bicarbonate (200 ml), 50% aqueous sodium chloride (2×200 ml), dry over anhydrous magnesium sulfate, filter and concentrate under vacuum to provide N-(2-amino-4,6-dioxo-3,5-dipropylcyclohex-1-enyl)-3-phenylbutyramide (2.23 g).

Fuente