Reacción #3740

Ecuación de reacción

2-amino-2-cyanoacetamide

trimethylorthoformate

n-Propylamine

→

title compound

Rendimiento 61.1%

5-Amino-1-n-propylimidazole-4-carboxamide

Rendimiento 61.1%

Disolventes

acetonitrile

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturawas heated
2. 2
   Temperaturaunder reflux for 0.75 hour
3. 3
   Temperaturato cool
4. 4
   OtroThe solid which precipitated
5. 5
   Filtraciónwas collected by filtration
6. 6
   Otrocrystallised from methanol

Procedimiento

A mixture of 2-amino-2-cyanoacetamide (2.8 g, 0.0282 mol), trimethylorthoformate (3.4 g, 0.0321 mol) and acetonitrile (55 ml) was heated under reflux for 0.75 hour, then allowed to cool. n-Propylamine (1.8 g, 0.0305 mol) was then added dropwise, and the resulting mixture stirred at ambient temperature for 36 hours. The solid which precipitated was collected by filtration and crystallised from methanol to give the title compound as a colourless solid (2.9 g, 61%), m.p. 241°-243° C. Found: C,49.67; H,7.15; N,33.64. C7 H12N4O requires C,49.98; H,7.19; N,33.31%.

Fuente