Reacción #3724

Ecuación de reacción

1,3-Di-n-butylxanthine

nitric acid

→

1,3-Di-n-butyl-8-nitro Xanthine

Disolventes

acetic acid

Condiciones de reacción

Tratamiento posterior

1. 1
   Filtraciónthe resulting yellow precipitate filtered off
2. 2
   Lavadowashed with water (50 ml)
3. 3
   workup.DISSOLUTIONThe yellow crystals were dissolved in dichloromethane
4. 4
   Lavadowashed twice with water
5. 5
   SecadoThe separated organic layer was then dried (anhydrous sodium sulphate)
6. 6
   Concentraciónconcentrated
7. 7
   Otroto give a crystalline product, yield 73 g (86%), m.pt 168° C.

Procedimiento

1,3-Di-n-butylxanthine (73 g, 0.28 mol) was dissolved in acetic acid (120 ml) and then treated with concentrated nitric acid (49 g) at 87° C. After 1 hour, the mixture was cooled to 5° C., the resulting yellow precipitate filtered off and washed with water (50 ml). The yellow crystals were dissolved in dichloromethane and washed twice with water. The separated organic layer was then dried (anhydrous sodium sulphate) and concentrated to give a crystalline product, yield 73 g (86%), m.pt 168° C.

Fuente