Reacción #3707

Ecuación de reacción

methyl 4-[2-(2-chlorophenyl)-2-oxoethyl]benzoate

NaOH

citric acid

→

desired product

Rendimiento 96.7%

4-[2-(2-Chlorophenyl)-2-oxoethyl]benzoic acid

Rendimiento 96.7%

Disolventes

CH3OH

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturais refluxed for 3 hours
2. 2
   OtroThe reaction mixture is evaporated in vacuo
3. 3
   Otroto remove the CH3OH
4. 4
   ExtracciónThe aqueous phase is extracted with CH2Cl2
5. 5
   OtroThe resulting solid is collected
6. 6
   Otrodried under vacuum

Procedimiento

A mixture of 18.78 g of methyl 4-[2-(2-chlorophenyl)-2-oxoethyl]benzoate in 288.8 ml of CH3OH, 72.2 ml of water and 5.2 g of NaOH is refluxed for 3 hours then acidified with 2N citric acid. The reaction mixture is evaporated in vacuo to remove the CH3OH. The aqueous phase is extracted with CH2Cl2 and acidified with 1N HCl. The resulting solid is collected and dried under vacuum to give 17.27 g of the desired product, m.p. 168°-172° C.

Fuente