Reacción #367655

Ecuación de reacción

2-amino-4-cyclopropyl-6-methylpyrimidine

sulfonyl isocyanate

2,3-Dihydro-2,2-dimethyl-7-benzofuransulfonyl isocyanate

→

N-[(4-Cyclopropyl-6-methylpyrimidin-2-yl)amino-carbonyl]-2,3-dihydro-2,2-dimethyl-7-benzofuransulfonamide

Disolventes

methylene chloride

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrothe residue is triturated with 1-chlorobutane
2. 2
   Filtraciónfiltered
3. 3
   Otroto give the subject compound

Procedimiento

To a suspension of 0.47 g of 2-amino-4-cyclopropyl-6-methylpyrimidine in 15 ml of methylene chloride is added one g of the sulfonyl isocyanate prepared in Example 4. After stirring at room temperature overnight, the suspension is concentratd in vacuo, and the residue is triturated with 1-chlorobutane and filtered to give the subject compound.

Fuente