Reacción #3646

Ecuación de reacción

hydrazine

4,10-dihydro-4-(4-nitrobenzoyl)-5H-pyrrolo-[1,2-a]thieno[3,2-e][1,4]diazepine

→

desired product

4,10-Dihydro-4-(4-aminobenzoyl)-5H-pyrrolo[1,2-a]thieno[3,2-e][1,4]diazepine

Disolventes

ethyl alcohol

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaheating
2. 2
   Temperaturaunder reflux for 3 hours
3. 3
   OtroThe cooled reaction mixture
4. 4
   Filtraciónis filtered through diatomaceous earth
5. 5
   ConcentraciónThe filtrate is concentrated in vacuo to a residue which
6. 6
   workup.DISSOLUTIONis dissolved in methylene chloride
7. 7
   ConcentraciónThe filtrate is concentrated in vacuo

Procedimiento

To a mixture of 5 mmol of 4,10-dihydro-4-(4-nitrobenzoyl)-5H-pyrrolo-[1,2-a]thieno[3,2-e][1,4]diazepine in 25 ml of ethyl alcohol is added 0.3 g of 10% Pd/C and 15 mmol of hydrazine followed by stirring and heating under reflux for 3 hours. The cooled reaction mixture is filtered through diatomaceous earth. The filtrate is concentrated in vacuo to a residue which is dissolved in methylene chloride and passed through a pad of hydrous magnesium silicate. The filtrate is concentrated in vacuo to give the desired product which is purified by flash chromatography on silica gel to give the desired product as a solid.

Fuente