Reacción #363176

Ecuación de reacción

2,5-dimethylaniline

acetic anhydride

→

2′,5′-dimethylacetanilide

Disolventes

dichloromethane

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturacooling
2. 2
   LavadoThe reaction mixture was washed with 1N hydrochloric acid
3. 3
   Secadoa saturated aqueous sodium bicarbonate solution subsequently, and dried over anhydrous magnesium sulfate
4. 4
   OtroRemoval of the solvent in vacuo

Procedimiento

To a stirred solution of 2,5-dimethylaniline (5.30 g) and 4-dimethylaminopyridine (6.41 g) in dichloromethane (90 ml) was added acetic anhydride (4.13 ml) under ice-cooling, and the mixture was stirred for 4 hours. The reaction mixture was washed with 1N hydrochloric acid and a saturated aqueous sodium bicarbonate solution subsequently, and dried over anhydrous magnesium sulfate. Removal of the solvent in vacuo gave 2′,5′-dimethylacetanilide (6.09 g).

Fuente