Reacción #362544

Ecuación de reacción

ethyl bromoacetate

3-(4-fluorophenyl)-5-methyl-l-(4-piperidyl)-1H-indole

3-(4-Fluorophenyl)-5-methyl-1-(4-piperidyl)-1H-indole

K2CO3

→

methyl 4-[3-(4-fluorophenyl)-5-methyl-1H-indol-1-yl]1-piperidinacetate

Disolventes

acetone

acetone

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroAfter another 2 h the solvents were evaporated
2. 2
   workup.ADDITIONwater was added
3. 3
   Extracciónthe mixture was extracted with ethyl acetate (2×100 ml)
4. 4
   LavadoThe combined organic phases were washed with brine
5. 5
   Secadodried (Na2SO4)
6. 6
   OtroEvaporation of the solvent

Procedimiento

A solution of ethyl bromoacetate in acetone was added during 15 min to a mixture of 3-(4-fluorophenyl)-5-methyl-l-(4-piperidyl)-1H-indole 3d (5.0 g), K2CO3 (2.5 g) and acetone (100 ml) at room temperature. After another 2 h the solvents were evaporated, water was added and the mixture was extracted with ethyl acetate (2×100 ml). The combined organic phases were washed with brine and dried (Na2SO4). Evaporation of the solvent afforded the crude methyl 4-[3-(4-fluorophenyl)-5-methyl-1H-indol-1-yl]1-piperidinacetate (6.0 g), which was used without further purification.

Fuente