Reacción #362543

Ecuación de reacción

1-(1-(N-methoxycarbonyl-2-aminoethyl)-4-piperidyl)-3-(4-fluorophenyl)-5-methyl-1H-indole

lithium aluminum hydride

water

NaOH

water

→

title compound

1-[1-(N-Methyl-2-aminoethyl)-4-piperidyl]-3-(4-fluorophenyl)-5-methyl-1H-indole

Disolventes

tetrahydrofuran

tetrahydrofuran

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturathe reaction mixture was refluxed for 1.5 h
2. 2
   workup.ADDITIONwere added
3. 3
   FiltraciónThe precipitate was filtered off
4. 4
   Secadothe solution was dried (Na2SO4)
5. 5
   Otrothe solvents were evaporated

Procedimiento

A solution of the crude 1-(1-(N-methoxycarbonyl-2-aminoethyl)-4-piperidyl)-3-(4-fluorophenyl)-5-methyl-1H-indole (8.8 g) in dry tetrahydrofuran (75 ml) was added to a suspension of lithium aluminum hydride (2 g) in dry tetrahydrofuran (75 ml) during 15 min and the reaction mixture was refluxed for 1.5 h. After cooling on an ice bath water (4 ml), 4N aqueous NaOH (2.5 ml) and water (10 ml) were added, succesively. The precipitate was filtered off, the solution was dried (Na2SO4) and the solvents were evaporated. This afforded the title compound, as an oil Yield: 6.9 g.

Fuente