Reacción #362541

Ecuación de reacción

3-(4-fluorophenyl)-5-methyl-l-(4-piperidyl)-1H-indole

3-(4-Fluorophenyl)-5-methyl-1-(4-piperidyl)-1H-indole

K2CO3

methyl chloroformate

→

title compound

Methyl 4-[3-(4-fluorophenyl)-5-methyl-1H-indol-1-yl]piperidine-1-carboxylate

Disolventes

dichloromethane

dichloromethane

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroAfter reaction for further 2 h at room temperature the reaction mixture
2. 2
   Lavadowas washed with water (2×100 ml)
3. 3
   Secadodried (MgSO4)
4. 4
   OtroEvaporation of the solvents in vacuo

Procedimiento

A mixture of 3-(4-fluorophenyl)-5-methyl-l-(4-piperidyl)-1H-indole 3d (6.0 g). K2CO3 (3.0 g) and dichloromethane (50 ml) was cooled to 0°-5° C. and a solution of methyl chloroformate (2.2 g)in dichloromethane (50 ml) was added during 0.5 h. After reaction for further 2 h at room temperature the reaction mixture was washed with water (2×100 ml) and dried (MgSO4). Evaporation of the solvents in vacuo afforded the title compound, which was used without further purification. Yield: 6.7 g, (oil).

Fuente