Reacción #362536

Ecuación de reacción

6-Chloro-3-(4-fluorophenyl)-1-(4-pyridyl)-lH-indole

6-Chloro-3-(4-fluorophenyl)-1-(4-pyridyl)-1H-indole

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title compound

Rendimiento 81.8%

6-Chloro-3-(4-fluorophenyl)-1-(4-piperidyl)-1H-indole

Rendimiento 81.8%

Disolventes

acetic acid

Condiciones de reacción

Tratamiento posterior

1. 1
   FiltraciónAfter hydrogenation for 30 h at 3 ato the catalyst was filtered off
2. 2
   Otrothe acetic acid was evaporated in vacuo and water (50 ml)
3. 3
   workup.ADDITIONwas added
4. 4
   Extracciónextracted with ethyl acetate (2×50 ml)
5. 5
   LavadoThe combined organic phases were successively washed with diluted sodium hydroxide (50 ml)
6. 6
   Lavadowashed with brine
7. 7
   Secadodried (Na2SO4)
8. 8
   OtroEvaporation of the solvent

Procedimiento

6-Chloro-3-(4-fluorophenyl)-1-(4-pyridyl)-lH-indole 2e (1.8 g) was dissolved in acetic acid (100 ml) and PtO2 (0.2 g) was added. After hydrogenation for 30 h at 3 ato the catalyst was filtered off, the acetic acid was evaporated in vacuo and water (50 ml) was added. The acidic solution was made alkaline (pH>9) with concentrated sodium hydroxide and extracted with ethyl acetate (2×50 ml). The combined organic phases were successively washed with diluted sodium hydroxide (50 ml), washed with brine, and dried (Na2SO4). Evaporation of the solvent gave 1.5 g of the title compound as an oil.

Fuente