Reacción #359502

ord-4d9daae6c7e045c6ad7e7c91147e04d8

Ecuación de reacción

Cc1c(C)c2c(c(C)c1N)C(c1ccc(F)cc1)C(C)(C)O2
3-(4-fluorophenyl)-2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-amine
CCOC(C)=O
Ethyl acetate
→
Cc1c(C)c(N2C(=O)c3ccccc3C2=O)c(C)c2c1OC(C)(C)C2c1ccc(F)cc1
title compound
Rendimiento 72.0%
Cc1c(C)c(N2C(=O)c3ccccc3C2=O)c(C)c2c1OC(C)(C)C2c1ccc(F)cc1
2-[3-(4-Fluorophenyl)-2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-yl]-1H-isoindole-1,3(2H)-dione
Rendimiento 72.0%

Reactantes

Cc1c(C)c2c(c(C)c1N)C(c1ccc(F)cc1)C(C)(C)O2
3-(4-fluorophenyl)-2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-amine
CCOC(C)=O
Ethyl acetate

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

By using 3-(4-fluorophenyl)-2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-amine, the title compound was synthesized according to Reference Example 35a. Yield: 72%. Melting point: 209-211° C. (Ethyl acetate)

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US07456162B2uspto-grants-2008_11