Reacción #357303

Ecuación de reacción

methyl 5-chloro-2,4-dihydroxybenzoate

1-(chloromethyl)-4-methoxybenzene

K2CO3

→

solid

Rendimiento 60.0%

Methyl 5-chloro-2-hydroxy-4-[(4-methoxybenzyl)oxy]benzoate

Rendimiento 60.0%

Disolventes

acetone

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe reaction mixture was heated
2. 2
   Temperaturawith reflux for 3 days
3. 3
   OtroThe inorganic material was removed by filtration
4. 4
   workup.DISTILLATIONThe solvent was distilled in vacuo
5. 5
   Otrothe residue was recrystallized from methanol

Procedimiento

To a solution of methyl 5-chloro-2,4-dihydroxybenzoate (0.41 g, 2 mmol) in acetone were added 1-(chloromethyl)-4-methoxybenzene (0.32 g, 2 mmol) and K2CO3 (0.28 g, 2 mmol). The reaction mixture was heated with reflux for 3 days, than cooled to room temperature. The inorganic material was removed by filtration. The solvent was distilled in vacuo, and the residue was recrystallized from methanol to afford white solid (0.37 g, 60%).

Fuente