Reacción #356891

Ecuación de reacción

potassium carbonate

4-phenylphenol

6-chloro-1-hexanol

→

4-(6-hydroxyhexyloxy)phenylbenzene

Rendimiento 85.1%

Disolventes

water

DMF

N,N-dimethylformamide

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONwas added with constant stirring
2. 2
   workup.WAITto proceed for 12 hours under constant stirring
3. 3
   Filtraciónthe precipitated solid was recovered by filtration
4. 4
   OtroThe resulting solid was then recrystallized from ethanol

Procedimiento

17 g of 4-phenylphenol (0.1 mol) was dissolved in 120 mL of N,N-dimethylformamide (hereafter abbreviated as DMF), 15.2 g of potassium carbonate powder (0.11 mol) was added with constant stirring, and the mixture was then stirred for one hour while heating at 90° C. Subsequently, 6-chloro-1-hexanol (14.3 g, 0.11 mol) was added dropwise to the mixture, and the reaction was allowed to proceed for 12 hours under constant stirring. Following confirmation by gas chromatography that the peaks derived from the raw materials had disappeared, the reaction mixture was diluted with water, and the precipitated solid was recovered by filtration. The resulting solid was then recrystallized from ethanol, yielding 23 g of 4-(6-hydroxyhexyloxy)phenylbenzene (yield: 85%).

Fuente