Reacción #356539

ord-18a07290b7e449ddb25e2bff4672baf3

Ecuación de reacción

C#Cc1cnn2c(C)cc(-c3ccc(C(F)(F)F)cc3)nc12
3-ethynyl-7-methyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine
Nc1ccc(Br)cn1
2-amino-5-bromopyridine
→
Cc1cc(-c2ccc(C(F)(F)F)cc2)nc2c(C#Cc3ccc(N)nc3)cnn12
title compound
Cc1cc(-c2ccc(C(F)(F)F)cc2)nc2c(C#Cc3ccc(N)nc3)cnn12
5-[7-Methyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidin-3-ylethynyl]-pyridin-2-ylamine

Reactantes

C#Cc1cnn2c(C)cc(-c3ccc(C(F)(F)F)cc3)nc12
3-ethynyl-7-methyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine
Nc1ccc(Br)cn1
2-amino-5-bromopyridine

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

The title compound was prepared from 3-ethynyl-7-methyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine (example C.12) (151 mg, 0.5 mmol) and 2-amino-5-bromopyridine (87 mg, 0.5 mmol) according to general procedure II. Obtained as an orange solid (37 mg, 19%). MS (ISP) 394.0 [(M+H)+].

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US07446113B2uspto-grants-2008_11