Reacción #355793

ord-aed7ddcd797741bbb437a779d794161e

Ecuación de reacción

O=C=Nc1cc(F)ccc1F

2,5-difluorophenyl isocyanate

CC(C)(C)[C@H](N)C(=O)N[C@@H]1CCN(Cc2ccccc2)C1

CC(C)(C)[C@H](N)C(=O)N[C@@H]1CCN(Cc2ccccc2)C1

2-(S)-Amino-N-(1-benzyl-pyrrolidin-3-(R)-yl)-3,3-dimethyl-butyramide

→

CC(C)(C)[C@H](NC(=O)Nc1cc(F)ccc1F)C(=O)N[C@@H]1CCN(Cc2ccccc2)C1

CC(C)(C)[C@H](NC(=O)Nc1cc(F)ccc1F)C(=O)N[C@@H]1CCN(Cc2ccccc2)C1

N-(1-Benzyl-pyrrolidin-3-(R)-yl)-2-(S)-[3-(2,5-difluoro-phenyl)-ureido]-3,3-dimethyl-butyramide

Reactantes

2,5-difluorophenyl isocyanate

2-(S)-Amino-N-(1-benzyl-pyrrolidin-3-(R)-yl)-3,3-dimethyl-butyramide

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas

See reaction.notes.procedure_details.

Procedimiento

Compound 3d was prepared from 2,5-difluorophenyl isocyanate and compound 2a using the method described in Example 9. MS (EI)=444 (M+).

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US07446115B2uspto-grants-2008_11