Reacción #354962

Ecuación de reacción

oxazolidinone

3'-isopropyl-7-nitro-3,4-dihydro-2H-1,5-benzodioxepin-3-spiro-5'-oxazolidin-2'-one

sodium hydroxide

water

→

3-hydroxy-3-isopropylaminomethyl-7-nitro-3,4-dihydro-2H-1,5-benzodioxepin

Disolventes

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrothe solution evaporated to a small volume
2. 2
   Extracciónthe product extracted with diethyl ether
3. 3
   OtroEvaporation of the solvent

Procedimiento

A mixture of 0.15 mole of the oxazolidinone from Step B above and 15 g. (0.38 mole) of sodium hydroxide in 100 ml. of water and 200 ml. of 95% ethanol is refluxed, the solution evaporated to a small volume and the product extracted with diethyl ether. Evaporation of the solvent gives 3-hydroxy-3-isopropylaminomethyl-7-nitro-3,4-dihydro-2H-1,5-benzodioxepin.

Fuente