Reacción #354960

Ecuación de reacción

3,7-Dihydroxy-3-isopropylaminomethyl-3,4-dihydro-2H-1,5-benzodioxepin

diazomethane

→

3-hydroxy-3-isopropylaminomethyl-7-methoxy-3,4-dihydro-2H-1,5-benzodioxepin

Disolventes

diethyl ether

diethyl ether

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroExcess diazomethane is destroyed by addition of a few drops of acetic acid
2. 2
   LavadoThe solution then is washed with water
3. 3
   Secadodried over anhydrous sodium sulfate
4. 4
   Otroevaporated to dryness

Procedimiento

3,7-Dihydroxy-3-isopropylaminomethyl-3,4-dihydro-2H-1,5-benzodioxepin (2.53 g.; 10 millimoles) from Example 89 dissolved in 50 ml. of diethyl ether is left 10 hours at ambient temperature with 0.46 g. (11 millimoles) of diazomethane in 25 ml. of diethyl ether. Excess diazomethane is destroyed by addition of a few drops of acetic acid. The solution then is washed with water, dried over anhydrous sodium sulfate, and evaporated to dryness to give 3-hydroxy-3-isopropylaminomethyl-7-methoxy-3,4-dihydro-2H-1,5-benzodioxepin.

Fuente