Reacción #354958

Ecuación de reacción

3-Acetoxy-3-N-acetylisopropylaminomethyl-7-amino-3,4-dihydro-2H-1,5-benzodioxepin

3-acetoxy-3-(N-acetylisopropylaminomethyl)-7-amino-3,4-dihydro-2H-1,5-benzodioxepin

ethyl chloroformate

pyridine

→

3-acetoxy-3-(N-acetylisopropylaminomethyl)-7-carbethoxyamino-3,4-dihydro-2H-1,5-benzodioxepin

Disolventes

chloroform

chloroform

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaheating in a water bath for several hours
2. 2
   Extracciónextracted with ether
3. 3
   Lavadothe combined ethereal extracts washed
4. 4
   Otrodried
5. 5
   Otroevaporated

Procedimiento

3-Acetoxy-3-N-acetylisopropylaminomethyl-7-amino-3,4-dihydro-2H-1,5-benzodioxepin (0.1 mole) from Example 86, Step B, in chloroform is treated with 0.11 mole of ethyl chloroformate and pyridine in chloroform. The mixture after stirring and heating in a water bath for several hours is diluted with water, extracted with ether, the combined ethereal extracts washed, dried and evaporated to give 3-acetoxy-3-(N-acetylisopropylaminomethyl)-7-carbethoxyamino-3,4-dihydro-2H-1,5-benzodioxepin.

Fuente