Reacción #3543

Ecuación de reacción

water

sodium hydride

2,6-dichlorophenylacetonitrile

4-amino-2-phenylamino-pyrimidine-5-carboxaldehyde

4-Amino-2-phenylamino-pyrimidine-5-carboxaldehyde

→

title compound

Rendimiento 68.4%

6-(2,6-Dichlorophenyl)-N2 -phenyl-pyrido[2,3-d]-pyrimidine-2,7-diamine

Rendimiento 68.4%

Disolventes

2-ethoxyethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe reaction was refluxed for 4 hours
2. 2
   Temperaturacooled
3. 3
   Extracciónextracted several times with dichloromethane
4. 4
   Lavadowashed with saturated sodium chloride
5. 5
   Secadodried with magnesium sulfate
6. 6
   Concentraciónconcentrated in vacuo
7. 7
   LavadoThe residue was washed with diethyl ether

Procedimiento

To a solution of 0.022 g 60% sodium hydride suspension in 2.00 mL of 2-ethoxyethanol was added 0.46 g of 2,6-dichlorophenylacetonitrile and 0.50 g of 4-amino-2-phenylamino-pyrimidine-5-carboxaldehyde from Example 72. The reaction was refluxed for 4 hours, cooled, poured into water, and extracted several times with dichloromethane. The dichloromethane washes were combined, washed with saturated sodium chloride, dried with magnesium sulfate, and concentrated in vacuo. The residue was washed with diethyl ether to give 0.61 g of the title compound, CIMS (1% NH3 in CH4): 410=M+ +C2H5, 382=M+ +H, 381=M+.

Fuente