Reacción #3504

Ecuación de reacción

sodium 2-ethoxyethoxide

sodium

2,4-diamino-5-pyrimidinecarboxaldehyde

2,6-dichlorophenylacetonitrile

→

2,7-diamino-6-(2,6-dichlorophenyl)-pyrido[2,3-d]pyrimidine

Disolventes

2-ethoxyethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   Otro(Prepared by the method of U.S
2. 2
   TemperaturaThe mixture is heated
3. 3
   Temperaturaat reflux for 4 hours
4. 4
   Temperaturacooled
5. 5
   Lavadothe insoluble product washed with diethylether

Procedimiento

(Prepared by the method of U.S. Pat. No. 3,534,039). To a solution of sodium 2-ethoxyethoxide prepared from 0.14 g of sodium and 60 mL of 2-ethoxyethanol was added 2.07 g of 2,4-diamino-5-pyrimidinecarboxaldehyde and 2.79 g of 2,6-dichlorophenylacetonitrile. The mixture is heated at reflux for 4 hours, cooled, and the insoluble product washed with diethylether to give 2,7-diamino-6-(2,6-dichlorophenyl)-pyrido[2,3-d]pyrimidine, mp 325-332° C. (MS).

Fuente