Reacción #3502

Ecuación de reacción

water

potassium carbonate

chloromethylpropargyl ether

N-methoxybenzamide

→

N-methoxy-N-propargyloxymethylbenzamide

Rendimiento 91.9%

Disolventes

acetonitrile

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONwas added to the reaction solution
2. 2
   Extracciónthe mixture was extracted with ethyl acetate
3. 3
   OtroThe extract was dried
4. 4
   Concentraciónconcentrated
5. 5
   Otropurified by silica gel column chromatography

Procedimiento

0.6 g of N-methoxybenzamide was dissolved in 10 ml of acetonitrile, and 0.55 g of potassium carbonate and 0.42 g of chloromethylpropargyl ether were added thereto in this order. The mixture was stirred at room temperature for 3 hours. After completion of the reaction, water was added to the reaction solution, and the mixture was extracted with ethyl acetate. The extract was dried, concentrated and purified by silica gel column chromatography to obtain 0.8 g of N-methoxy-N-propargyloxymethylbenzamide.

Fuente