Reacción #3501

Ecuación de reacción

N-methoxy-2,4-dichlorobenzamide

potassium carbonate

propargyl bromide

N,N-dimethylformamide

→

propargyl N-methoxy-2,4-dichlorobenzimidate

Rendimiento 29.8%

Disolventes

water

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONwas added to the reaction solution
2. 2
   Extracciónthe mixture was extracted with ethyl acetate
3. 3
   OtroThe extract was dried
4. 4
   Concentraciónconcentrated
5. 5
   Otropurified by silica gel column chromatography

Procedimiento

1.0 g of N-methoxy-2,4-dichlorobenzamide, 0.75 g of potassium carbonate and 0.65 g of propargyl bromide were added to 10 ml of N,N-dimethylformamide, and the mixture was stirred for 3 hours. After completion of the reaction, water was added to the reaction solution, and the mixture was extracted with ethyl acetate. The extract was dried, concentrated and purified by silica gel column chromatography to obtain 0.35 g of propargyl N-methoxy-2,4-dichlorobenzimidate.

Fuente