Reacción #3491

Ecuación de reacción

KOH

6-chloropurine

HCl

3,5-diacetylaniline

→

6-[(3,5-diacetylphenyl)amino]purine

Rendimiento 90.4%

Disolventes

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaheated
2. 2
   Temperaturaat reflux for 30 min
3. 3
   TemperaturaAfter cooling the mixture
4. 4
   Filtraciónthe solid was filtered out
5. 5
   Lavadowashed with water
6. 6
   Otrodried

Procedimiento

Compound No. 16: A suspension of 3,5-diacetylaniline (0.531 g) in water (10 mL) was treated with 6-chloropurine (0.464 g) and concentrated HCl (0.25 mL) and heated at reflux for 30 min. After cooling the mixture was treated with 6 mL of aqueous 1N KOH. The mixture was stirred for 10 min and the solid was filtered out, washed with water, and dried, to give 0.80 g of 6-[(3,5-diacetylphenyl)amino]purine, mp dec 340°-350° C.

Fuente