Reacción #3490

Ecuación de reacción

KOH

m-aminoacetophenone

2-amino-4-chloro-6-methylpyrimidine

HCl

→

4-(3-acetylphenyl)amino-2-amino-6-methylpyrimidine

Rendimiento 78.5%

Disolventes

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaheated
2. 2
   Temperaturaat reflux for 1 hour
3. 3
   Otrogave a light buff solid, which
4. 4
   Filtraciónwas filtered out
5. 5
   Otrodried

Procedimiento

Compound No. 15: A suspension of m-aminoacetophenone (2.7 g) and 2-amino-4-chloro-6-methylpyrimidine (2.87 g) in 40 mL water was treated with 1.7 mL concentrated HCl and heated at reflux for 1 hour. Addition of 40 mL 1N KOH gave a light buff solid, which was filtered out and dried to give 3.8 g 4-(3-acetylphenyl)amino-2-amino-6-methylpyrimidine, mp 196°-98° C.

Fuente