Reacción #348499

Ecuación de reacción

2,2,2-trichloroethyl 6-(α-t-butyloxycarbonylaminophenylacetamido)-2,2-dimethylpenam-3-carboxylate-1-oxide

N-chlorosuccinimide

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title product

2,2,2-Trichloroethyl 3-methyl-2-[2-chlorosulfinyl-4-oxo-3-(α-t-butyloxycarbonylaminophenylacetamido)-1-azetidinyl]-3-butenoate

Condiciones de reacción

Tratamiento posterior

1. 1
   Secadoof toluene was dried azeotropically by distillation of about 50 ml
2. 2
   workup.ADDITIONTo the dried solution was added 0.685 g
3. 3
   TemperaturaThe resulting mixture was refluxed for 70 minutes
4. 4
   Filtraciónwas filtered
5. 5
   Otroevaporated in vacuo to dryness

Procedimiento

A solution of 2.85 g. (5 mmol) of 2,2,2-trichloroethyl 6-(α-t-butyloxycarbonylaminophenylacetamido)-2,2-dimethylpenam-3-carboxylate-1-oxide in 175 ml. of toluene was dried azeotropically by distillation of about 50 ml. of toluene from the mixture. To the dried solution was added 0.685 g. (5.5 mmol.) of N-chlorosuccinimide. The resulting mixture was refluxed for 70 minutes. The mixture was allowed to cool to room temperature and then was filtered and evaporated in vacuo to dryness to provide the title product (contaminated with succinimide).

Fuente