Reacción #347449

Ecuación de reacción

sodium hydride

adenine

N-(4-bromobutyl)-phthalimide

→

expected product

Rendimiento 63.3%

N-[4-(6-amino-9H-purin-9-yl)-3-butenyl]-phthalimide

Rendimiento 63.3%

Disolventes

dimethylformamide

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.STIRRINGthe mixture was stirred at ambient temperature for 74 hours
2. 2
   Filtraciónby filtering
3. 3
   OtroThe solvent of the filtrate was evaporated
4. 4
   Lavadothe precipitate was washed with ether, with water, with ethanol
5. 5
   Secadoagain with ether and dried
6. 6
   workup.DISSOLUTIONThe residue was dissolved in methanol at 65° C.
7. 7
   Temperaturachilled

Procedimiento

3.4 g of sodium hydride were added to 9.6 g of adenine in 270 ml of dimethylformamide and the mixture was stirred for 2 hours and 30 minutes. 20 g of N-(4-bromobutyl)-phthalimide were added and the mixture was stirred at ambient temperature for 74 hours, followed by filtering. The solvent of the filtrate was evaporated and the precipitate was washed with ether, with water, with ethanol, then again with ether and dried. The residue was dissolved in methanol at 65° C. and chilled to obtain 15.00 g of the expected product.

Fuente