Reacción #346449

Ecuación de reacción

2,3-Epoxypropyl isopropyl ether

sodium hydride

n-dodecylthiol

→

1-(n-dodecylthio)-3-isopropoxy-2-propanol

Disolventes

tetrahydrofuran

tetrahydrofuran

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroformed by the addition of 50 mg
2. 2
   OtroAfter approximately 4 hours the solvent is removed from the reaction mixture and 20 ml
3. 3
   workup.ADDITIONof water is added to the residue
4. 4
   ExtracciónThe resultant aqueous mixture is extracted with ether
5. 5
   Lavadothe ether extracts washed with water
6. 6
   Secadodried over magnesium sulfate
7. 7
   Otroevaporated

Procedimiento

2,3-Epoxypropyl isopropyl ether (1.16 g.) in several ml. of dry tetrahydrofuran is added to a stirred suspension formed by the addition of 50 mg. of sodium hydride (56% dispersion in mineral oil) to 2.2 g. 8. of n-dodecylthiol in 50 ml. tetrahydrofuran. The mixture is then stirred at 60° C. After approximately 4 hours the solvent is removed from the reaction mixture and 20 ml. of water is added to the residue. The resultant aqueous mixture is extracted with ether and the ether extracts washed with water, dried over magnesium sulfate and evaporated to yield 1-(n-dodecylthio)-3-isopropoxy-2-propanol.

Fuente