Reacción #346256

Ecuación de reacción

1-butylpiperazine

3,4-dimethoxy-3-cyclobutene-1,2-dione

→

3,4-bis(4-butyl-1-piperazinyl)-3-cyclobutene-1,2-dione

Disolventes

ethanol

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThen, the solvent is removed with a nitrogen stream, 5 ml
2. 2
   workup.ADDITIONof anhydrous ethyl ether is added
3. 3
   Filtraciónthe resultant solid is filtered
4. 4
   Lavadowashed with ethyl ether
5. 5
   Otrodried in air

Procedimiento

To a solution of 0.9 grams of 3,4-dimethoxy-3-cyclobutene-1,2-dione dissolved in 10 ml. of absolute ethanol is added 1.8 grams of 1-butylpiperazine in 5 ml. of absolute ethanol. The reaction mixture is stirred overnight at room temperature under a nitrogen atmosphere. Then, the solvent is removed with a nitrogen stream, 5 ml. of anhydrous ethyl ether is added, and the resultant solid is filtered, washed with ethyl ether, and dried in air. The resulting product, 3,4-bis(4-butyl-1-piperazinyl)-3-cyclobutene-1,2-dione is obtained as white crystals melting at approximately 137.5°-139° C.

Fuente