Reacción #346247

Ecuación de reacción

1-decanol

mesyl chloride

→

decyl methylsulfonate

Disolventes

n-hexane

collidine

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONpoured onto ice
2. 2
   ExtracciónThe reaction mixture is extracted with ether
3. 3
   Lavadothe ether extracts are washed with 10% hydrochloric acid
4. 4
   Secadodried over anhydrous sodium sulfate
5. 5
   Otrothe solvent removed under reduced pressure
6. 6
   Otroto leave an oil which
7. 7
   Temperaturaupon cooling
8. 8
   Temperaturacooled

Procedimiento

To a cooled solution of 158.3 grams of 1-decanol in 1.0 liter of collidine is added dropwise 126 grams of mesyl chloride. The resulting mixture is stirred at room temperature for 1.5 hours and then poured onto ice. The reaction mixture is extracted with ether and the ether extracts are washed with 10% hydrochloric acid. The ether extracts are combined, dried over anhydrous sodium sulfate, and the solvent removed under reduced pressure to leave an oil which solidifies upon cooling. The oil is dissolved in n-hexane and cooled to yield as crystals, decyl methylsulfonate.

Fuente