Reacción #345581

Ecuación de reacción

β-ionone

Phosphonate

6-diethylphosphono-3-methyl-2,4-hexadienal dioxolane

Potassium tert-butylate

→

Retinal

Disolventes

THF

THF

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.WAITThe solution was kept at -70° C. for 15 minutes
2. 2
   workup.WAITat -20° C. for 1 hour

Procedimiento

Phosphonate (I) (0.5 g, 1.72 mmol) in solution in THF (10 ml) was introduced under argon into a 25-ml two-necked flask. Potassium tert-butylate (0.275 g, 2.22 mmol) was added in small portions at -70° C. Stirring was continued at -70° C. for 90 minutes. β-ionone (0.34 g, 1.8 mmol) in solution in THF (1 ml) was then added. The solution was kept at -70° C. for 15 minutes and then at -20° C. for 1 hour.

Fuente