Reacción #345555

Ecuación de reacción

phenyl cyanamide

1,2-epoxy butane

potassium carbonate

→

desired product

2-Imino-3-phenyl-5-ethyl-1,3-oxazolidine

Disolventes

methyl ethyl ketone

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroIn a flask were combined
2. 2
   FiltraciónIt was then filtered
3. 3
   Otrothe methyl ethyl ketone removed in vacuo
4. 4
   OtroThe solids recovered from the filter
5. 5
   Extracciónwere extracted with acetone
6. 6
   workup.DISSOLUTIONThe combined solids were dissolved in water
7. 7
   OtroThe solvents were removed in vacuo
8. 8
   Otroproducing

Procedimiento

In a flask were combined 3.0 grams (g) (25.4 mmol) phenyl cyanamide, 1.83 g (25.4 mmol) 1,2-epoxy butane, 3.51 g (25.4 mmol) potassium carbonate and 50 milliliters (ml) methyl ethyl ketone. The mixture was stirred overnight under a nitrogen blanket at room temperature. It was then filtered and the methyl ethyl ketone removed in vacuo. The solids recovered from the filter were extracted with acetone and combined with the residue from the main portion. The combined solids were dissolved in water and extraced with 15% isopropanol in chloroform. The solvents were removed in vacuo producing 2.30 g (48% of theoretical yield) of the desired product. Spectroscopic analysis confirmed the structure of the desired product. No type II product was detected.

Fuente