Reacción #344409

Ecuación de reacción

nitric acid

sulphuric acid

6,7-dibromo-2,2,3,3-tetrafluoro-benzo (1.4)dioxane

→

6,7-dibromo-5-nitro-2,2,3,3-tetrafluoro-benzo(1.4)dioxane

Rendimiento 88.0%

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONpoured onto ice
2. 2
   Extracciónextracted thoroughly with ether
3. 3
   Lavadothe extract is washed with water and sodium hydrogen carbonate solution (until neutral)
4. 4
   Secadodried over magnesium sulphate
5. 5
   Otrothe ether is removed

Procedimiento

A precooled mixture of 19 ml of nitric acid and 26 ml of concentrated sulphuric acid is slowly added dropwise at 5° C. to 73 g (0.2 mol) of 6,7-dibromo-2,2,3,3-tetrafluoro-benzo (1.4)dioxane. The mixture is subsequently stirred at 5° C. for 4 hours, poured onto ice and extracted thoroughly with ether, the extract is washed with water and sodium hydrogen carbonate solution (until neutral), and dried over magnesium sulphate, and the ether is removed. 72 g (88% of theory) of 6,7-dibromo-5-nitro-2,2,3,3-tetrafluoro-benzo(1.4)dioxane having the melting point 91° to 92° C. are isolated.

Fuente