Reacción #3429

Ecuación de reacción

HCl

7a-(5-phenyl-3-pyridinyl)-hexahydro-1H-pyrrolizine

→

title compound

7a-(5-phenyl-3-pyridinyl)-hexahydro-1H-pyrrolizine hydrochloride salt

Disolventes

Et2O

ether

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe solvent was removed
2. 2
   Otrothe solid was dried

Procedimiento

The 7a-(5-phenyl-3-pyridinyl)-hexahydro-1H-pyrrolizine compound from step 25b was dissolved in ether (5 mL) and Et2O saturated with HCl (g) was added. The solvent was removed, and the solid was dried to afford the title compound as yellow needles (13.5 mg): mp 217°-220° C. (dec.); 1H NMR D2O, 300 MHz) δ2.17-2.47 (m, 4H), 2.57-2.73 (m, 4H), 3.41-3.50 (m, 2H), 3.87-3.97 (m, 2H), 7.60-7.68 (m, 3H), 7.75-7.81 (m, 2H), 8.60 (dd, J=2.0, 2.0 Hz, 1H), 8.87 (d, J=2.0 Hz, 1H), 9.04 (d, J=2.0 Hz, 1H); MS (CI/NH3) m/z: 265 (M+H)+. Anal. Calcd for C18H20N2.2.0 HCl.0.1 H2O: C, 63.76; H, 6.60; N, 8.26. Found: C, 63.62; H, 6.48; N, 8.02.

Fuente