Reacción #3422

Ecuación de reacción

HCl

7a-(5-bromo-6-fluoro-3-pyridinyl)-hexahydro-1H-pyrrolizine

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title compound

Rendimiento 87.0%

7a-(5-bromo-6-fluoro-3-pyridinyl)-hexahydro-1H-pyrrolizine hydrochloride salt

Rendimiento 87.0%

Disolventes

Et2O

Et2O

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe solvent was removed
2. 2
   Otrothe solid was triturated with Et2O
3. 3
   Otrodried

Procedimiento

7a-(5-bromo-6-fluoro-3-pyridinyl)-hexahydro-1H-pyrrolizine was dissolved in Et2O, and Et2O saturated with HCl (g) was added. The solvent was removed, and the solid was triturated with Et2O and dried to afford the title compound as a white powder (59 mg, 87%): mp 213°-215° C.; 1H NMR D2O, 300 MHz) δ2.15-2.49 (m, 6H), 2.56-2.65 (m, 2H), 3.34-3.42 (m, 2H), 3.78-3.87 (m, 2H), 8.31 (dd, J=2.4, 1.0 Hz, 1H), 8.38 (dd, J=7.8, 2.4 Hz, 1H); MS (CI/NH3) m/z: 285/287 (M+H)+; MS (CI/NH3): m/z 285/287 (M+H+). Anal. Calcd for C12H14BrFN2.HCl: C, 44.81; H, 4.70; N, 8.71. Found: C, 45.04; H, 4.25; N, 8.48.

Fuente