Reacción #341074

ord-5a072e57e2584107a11cacf566acb00c

Ecuación de reacción

N#CSc1cnc(NC(=O)N(C2CCCCC2)C2CCCCC2)s1
1,1-dicyclohexyl-3-(5-thiocyanato-thiazol-2-yl)-urea
O[C@H](CS)[C@@H](O)CS
dithioerythritol
ClCC=NCCCCCCCl
2-(hexamethyleneimino)ethylchloride
→
O=C(Nc1ncc(SCCN2CCCCCC2)s1)N(C1CCCCC1)C1CCCCC1
3-[5-(2-Azepan-1-yl-ethylsulfanyl)-thiazol-2-yl]-1,1-dicyclohexyl-urea

Reactantes

N#CSc1cnc(NC(=O)N(C2CCCCC2)C2CCCCC2)s1
1,1-dicyclohexyl-3-(5-thiocyanato-thiazol-2-yl)-urea
O[C@H](CS)[C@@H](O)CS
dithioerythritol
ClCC=NCCCCCCCl
2-(hexamethyleneimino)ethylchloride

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    OtroPrepared

Procedimiento

Prepared as described in general procedure (H) using 1,1-dicyclohexyl-3-(5-thiocyanato-thiazol-2-yl)-urea, dithioerythritol and 2-(hexamethyleneimino)ethylchloride

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US07872139B2uspto-grants-2011_01