Reacción #341073

ord-369a8a4a72c9454ca62c542c80651cec

Ecuación de reacción

N#CSc1cnc(NC(=O)N(C2CCCCC2)C2CCCCC2)s1
1,1-dicyclohexyl-3-(5-thiocyanato-thiazol-2-yl)-urea
O[C@H](CS)[C@@H](O)CS
dithioerythritol
ClCC1=NCCN1
2-chloromethyl-2-imidazoline
→
O=C(Nc1ncc(SCC2=NCCN2)s1)N(C1CCCCC1)C1CCCCC1
1,1-Dicyclohexyl-3-[5-(4,5-dihydro-1H-imidazol-2-ylmethylsulfanyl)-thiazol-2-yl]-urea

Reactantes

N#CSc1cnc(NC(=O)N(C2CCCCC2)C2CCCCC2)s1
1,1-dicyclohexyl-3-(5-thiocyanato-thiazol-2-yl)-urea
O[C@H](CS)[C@@H](O)CS
dithioerythritol
ClCC1=NCCN1
2-chloromethyl-2-imidazoline

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    OtroPrepared

Procedimiento

Prepared as described in general procedure (H) using 1,1-dicyclohexyl-3-(5-thiocyanato-thiazol-2-yl)-urea, dithioerythritol and 2-chloromethyl-2-imidazoline.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US07872139B2uspto-grants-2011_01