Reacción #341002

ord-68a038b2a38d4ab4b7ce6b4fea965715

Ecuación de reacción

NC(N)=O
urea
C[C@H]1CC[C@H](NC2CCCCC2)CC1
cyclohexyl-(trans-4-methyl-cyclohexyl)-amine
Nc1ncc(C=O)s1
2-amino-5-formylthiazole
→
C[C@H]1CC[C@H](N(C(=O)Nc2ncc(C=O)s2)C2CCCCC2)CC1
Trans-1-cyclohexyl-3-(5-formyl-thiazol-2-yl)-1-(4-methyl-cyclohexyl)-urea

Reactantes

NC(N)=O
urea
C[C@H]1CC[C@H](NC2CCCCC2)CC1
cyclohexyl-(trans-4-methyl-cyclohexyl)-amine
Nc1ncc(C=O)s1
2-amino-5-formylthiazole

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    OtroPrepared in 40% (140 mg)
  2. 2
    Otroyield

Procedimiento

Prepared in 40% (140 mg) yield as described for 1,1-dicyclohexyl-3-5-formyl-thiazol-2-yl)-urea using cyclohexyl-(trans-4-methyl-cyclohexyl)-amine (195 mg, 1.0 mmol) and 2-amino-5-formylthiazole (128 mg, 1.0 mmol).

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US07872139B2uspto-grants-2011_01