Reacción #339873

Ecuación de reacción

hydrochloric acid

sodium boron hydride

water

methyl 2-hydroxy-3,3,3-trifluoro-2-trifluoromethylpropionate

→

3,3,3-trifluoro-2-trifluoromethyl-1,2-propane diol

Rendimiento 96.0%

Disolventes

diethyl ether

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.STIRRINGThe mixture was stirred for 10 hours
2. 2
   Otroto quench
3. 3
   Otrothe reaction
4. 4
   OtroAn organic layer was separated from the reaction mixture
5. 5
   Concentraciónconcentrated
6. 6
   workup.DISTILLATIONdistilled

Procedimiento

To a mixture of 25.0 g of sodium boron hydride, 500 g of water, and 500 g of diethyl ether, with stirring, 100 g of methyl 2-hydroxy-3,3,3-trifluoro-2-trifluoromethylpropionate was added dropwise. The mixture was stirred for 10 hours, after which hydrochloric acid was added to quench the reaction. An organic layer was separated from the reaction mixture, concentrated, and distilled, obtaining 83.9 g of 3,3,3-trifluoro-2-trifluoromethyl-1,2-propane diol (yield 96%).

Fuente