Reacción #339341

Ecuación de reacción

6-Methoxybenzo[b]thiophene

pyridine hydrochloride

→

title compound

Rendimiento 98.5%

Benzo[b]thiophen-6-ol

Rendimiento 98.5%

Disolventes

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Extracciónextracted with dichloromethane (3×70 mL)
2. 2
   LavadoThe combined extracts were washed with water (125 mL)
3. 3
   Secadodried (MgSO4)
4. 4
   Otroevaporated in vacuo

Procedimiento

6-Methoxybenzo[b]thiophene (6.15 g, 37.45 mmol) and pyridine hydrochloride (18.5 g) were heated together at 210° C. for 1 h. The mixture was cooled to 100° C., diluted with water (125 mL) and extracted with dichloromethane (3×70 mL). The combined extracts were washed with water (125 mL), dried (MgSO4) and evaporated in vacuo to give the title compound (5.54 g, 98%)

Fuente