Reacción #339171

ord-0ef1d4248feb43bf94b6713dad422d0c

Ecuación de reacción

Cc1cc(Cl)cc(C(=O)O)c1N
2-amino-5-chloro-3-methylbenzoic acid
O=C(O)c1cc(Br)cn1-c1ncccc1C(F)(F)F
4-bromo-1-(3-trifluoromethyl-2-pyridinyl)-1H-pyrrole-2-carboxylic acid
Nc1c(Br)cc(Br)cc1C(=O)O
2-amino-3,5-dibromobenzoic acid
O=C(O)c1cc(Br)cn1-c1ncccc1Cl
4-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrrole-2-carboxylic acid
O=c1oc(-c2cc(Br)cn2-c2ncccc2C(F)(F)F)nc2c(Br)cc(Br)cc12
6,8-dibromo-2-[4-bromo-1-(3-trifluoromethyl-2-pyridinyl)-1H-pyrrol-2-yl]-4H-3,1-benzoxazine-4-one

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

According to the same manner as that of Reference Preparation Example 71-(5), 4-bromo-1-(3-trifluoromethyl-2-pyridinyl)-1H-pyrrole-2-carboxylic acid and 2-amino-3,5-dibromobenzoic acid were used in place of 4-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrrole-2-carboxylic acid and 2-amino-5-chloro-3-methylbenzoic acid respectively to obtain 6,8-dibromo-2-[4-bromo-1-(3-trifluoromethyl-2-pyridinyl)-1H-pyrrol-2-yl]-4H-3,1-benzoxazine-4-one of the formula:

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US07867949B2uspto-grants-2011_01