Reacción #339163

ord-d176981e7b294fd88206c8da225f742f

Ecuación de reacción

Cc1cc(Cl)cc(C(=O)O)c1N
2-amino-5-chloro-3-methylbenzoic acid
O=C(O)c1cc(Cl)c(Cl)n1-c1ncccc1Cl
4,5-dichloro-1-(3-chloro-2-pyridinyl)-1H-pyrrole-2-carboxylic acid
Nc1c(C(=O)O)cc2cc(Br)ccc2c1Cl
3-amino-7-bromo-4-chloro-2-naphthoic acid
O=C(O)c1cc(Br)cn1-c1ncccc1Cl
4-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrrole-2-carboxylic acid
O=c1oc(-c2cc(Cl)c(Cl)n2-c2ncccc2Cl)nc2c(Cl)c3ccccc3cc12
10-chloro-2-[4,5-dichloro-1-(3-chloro-2-pyridinyl)-1H-pyrrol-2-yl]-4H-naphtho[2,3-d][1,3]oxazine-4-one

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

According to the same manner as that of Reference Preparation Example 71-(5), 4,5-dichloro-1-(3-chloro-2-pyridinyl)-1H-pyrrole-2-carboxylic acid and 3-amino-7-bromo-4-chloro-2-naphthoic acid were used in place of 4-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrrole-2-carboxylic acid and 2-amino-5-chloro-3-methylbenzoic acid respectively to obtain 10-chloro-2-[4,5-dichloro-1-(3-chloro-2-pyridinyl)-1H-pyrrol-2-yl]-4H-naphtho[2,3-d][1,3]oxazine-4-one of the formula:

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US07867949B2uspto-grants-2011_01