Reacción #338670

Ecuación de reacción

isopropylalcohol

sodium hydroxide

compound 9

2-Ethoxycarbonyl-1-methyl-4-{4-(1-methylimidazole-2-carboxamido)-1-methypyrrole-2-carboxamido}imidazole

hydrochloric acid

→

compound 10

Rendimiento 96.6%

Sodium 1-methyl-4-{4-(1-methylimidazole-2-carboxamido)-1-methypyrrole-2-carboxamido}imidazole-2-carboxylate

Rendimiento 96.6%

Disolventes

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaAfter being cooled to a room temperature
2. 2
   Otroto give the white powder, which
3. 3
   Filtraciónwas then filtered

Procedimiento

The compound 9 (3.0 g, 7.5 mmol) was dissolved in methanol (37.6 ml), mixed with aqueous solution of sodium hydroxide (37.6 ml, 7.89 mmol) and stirred for one hour at 50° C. After being cooled to a room temperature, the resulting solution was mixed with hydrochloric acid (1N) to reach pH 2.0, and then mixed with isopropylalcohol to give the white powder, which was then filtered to give the compound 10 (2.85 g, 94%).

Fuente